A-1208746 - CAS 1668553-23-8

A-1208746 is an inhibitor of MCL-1 with a Ki value of 0.454 nM. This compound effectively activates caspase-3/-7, induces apoptosis in H929 cells, and reduces mitochondrial membrane potential. Additionally, A-1208746 synergizes with Navitoclax, making it applicable in cancer research.

Apoptosis, Bcl-2 Family

Apoptosis

1668553-23-8

C45H52N6O7S

821

O=C(O)C1=C(C=2C=CC=C(C=3C(=NN(C3COC4=CC=C(C=C4)N5CCN(CC5)S(=O)(=O)C)C)C)C2N1CCN6CCOCC6)CCCOC7=CC=CC=8C=CC=CC78

-20°C

Ice Packs

Small Compound