A-3 hydrochloride - CAS 78957-85-4

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1], and also inhibits PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM), and myosin light chain kinase (MLCK) (Ki=7.4 μM) .

PKC, PKA, Casein Kinase, CaMK

Neuroscience, Stem Cells, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Cytoskeletal Signaling, Metabolism

78868

0.9979

C12H14Cl2N2O2S

321.22

Cl.NCCNS(=O)(=O)c1cccc2c(Cl)cccc12

-20°C

Ice Packs

Small Compound