Aβ42-IN-1 - CAS 2582757-69-3

Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM) . Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ42-IN-1 shows a sustained pharmacokinetic profile.

Others, Gamma-secretase

Neuroscience, Others, Stem Cells, Proteases/Proteasome

2582685

C29H27ClN4O2

499

O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=CC=C5)C=C4)=CC=CN32)C=C1)NCC.[H]Cl

-20°C

Ice Packs

Small Compound