Aβ42-IN-1 free base - CAS 2434633-17-5

Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels with an IC50 of 0.091 μM, and significantly diminishes brain Aβ42 levels in mice. Given these properties, Aβ42-IN-1 free base represents a potential disease-modifying agent for Alzheimer's disease [1].

Others, Gamma-secretase

Others, Proteases/Proteasome, Neuroscience, Stem Cells

2434611

C29H26N4O2

462.54

CC1=C(N2C(=N1)C(OCC3=CC=C(C=C3)C4=CC=CC=C4)=CC=C2)C=5C=CC(C(NCC)=O)=NC5

-20°C

Ice Packs

Small Compound