A-674563 HCl (552325-73-2 (free base) ) - CAS 2070009-66-2

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1].

Akt, ERK, PKA, PKC, CDK

Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, MAPK, Chromatin/Epigenetic, Cytoskeletal Signaling

2069941

0.9969

C22H23ClN4O

394.9

CC=1C=2C(=CC=C(C2)C=3C=C(OC[C@H](CC4=CC=CC=C4)N)C=NC3)NN1.Cl

-20°C

Ice Packs

Small Compound