A-77636 - CAS 778546-51-3

A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 value of 8.13. It demonstrates the highest affinity for the dopamine D1 receptor with a dissociation constant (Ki) of 39.8 nM and a pKi of 7.40 ± 0.09. Notably, A-77636 exhibits antiparkinsonian activity [1].

Dopamine Receptor

GPCR/G Protein, Neuroscience

778492

C20H27NO3

329.43

C(N)[C@@H]1O[C@H]([C@]23CC4(CC(C2)(CC(C3)(C4)[H])[H])[H])CC=5C1=CC=C(O)C5O

-20°C

Ice Packs

Small Compound