A-800141 - CAS 681245-85-2

A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM) . GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.

Aminopeptidase

Metabolism

681158

C24H30N2O4S

442.571

C(O)(=O)C1=C2C(=CC=C1NS(=O)(=O)C3=C(/C=C\CN(CC)CC)C=CC=C3)CCCC2

-20°C

Ice Packs

Small Compound