A 80b - CAS 135561-94-3

A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-80b shows dose-dependent inhibition of the Ca (2+) -induced contraction. Hypotensive and antihypertensive effect of A-80b possibly attributable to vasodilator activity via interference with Ca2+ influx and probably Ca2+ mobilization from intracellular stores.

Calcium Channel, Others

Metabolism, Others, Membrane transporter/Ion channel

135464

C16H17N7

307.35

N(NC)=C1C2=C(C(=NN1)N3N=C(C)C=C3C)NC=4C2=CC=CC4

-20°C

Ice Packs

Small Compound