A-86929 - CAS 171961-95-8

A-86929 is a potent and selective dopamine D1 receptor agonist with a pKi of 7.3. It significantly induces rotational behavior in a 6-OHDA-induced unilateral nigral lesion rat model and improves motor function in an MPTP-induced Parkinson's disease marmoset model. Furthermore, A-86929 shows potential value in reducing cocaine-induced craving behavior in rats and reversing Haloperidol-induced cognitive deficits in rhesus monkeys. The compound is useful for researching neurological disorders.

Dopamine Receptor

Neuroscience, GPCR/G Protein

171858

C18H21NO2S

315.43

C(CC)C1=CC=2[C@@]3(C=4C(CC[C@]3(NCC2S1)[H])=CC(O)=C(O)C4)[H]

-20°C

Ice Packs

Small Compound