A-889425 - CAS 1072921-02-8

A-889425 is a selectively active oral TRPV1 receptor antagonist with IC50 values of 335 nM (rat) and 34 nM (human) . This compound effectively penetrates the central nervous system, reducing mechanical allodynia and the response of spinal neurons to mechanical stimuli in rat paws following inflammation induced by Complete Freund's Adjuvant.

TRP/TRPV Channel

Membrane transporter/Ion channel

1072921-02-8

C19H18F3N3O3S

425.42

O=C(NC1=CC=C(C=C1)S(=O)(=O)C(F)(F)F)C2=CCN(C3=NC=CC=C3C)CC2

-20°C

Ice Packs

Small Compound