A-971432 - CAS 1240308-45-5

A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 &#181M, respectively) . It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM) . A-971432 (1 &#181M) increases electrical resistance of hCMEC/D3 cells in an in vitro blood-brain barrier model, indicating enhanced barrier integrity, and attenuates blood-brain barrier leakage in an R6/2 transgenic mouse model of Huntington's disease when administered at a dose of 0.1 mg/kg.[1] [2] A-971432 (0.1 mg/kg per day, i.p.) decreases the number of errors made in a horizontal ladder task and increases latency to fall in the rotarod test in R6/2 mice. It also increases spontaneous alternation in the t-maze in aged mice when administered at a dose of 0.1 mg/kg.[1]

LPL Receptor, Others

GPCR/G Protein, Others

1240258

C18H17Cl2NO3

366.24

C(N1CC(C(O)=O)C1)C2=CC=C(OCC3=CC(Cl)=C(Cl)C=C3)C=C2

-20°C

Ice Packs

Small Compound