αA-Conotoxin OIVA - CAS 878027-87-3

αA-Conotoxin OIVA (αA-OIVA), a peptide derived from conotoxin, is a selective nAChR antagonist with an IC50 of 56 nM against mammalian fetal muscle nAChR, resulting in muscle paralysis [1] [2].

AChR

Neuroscience

877937

C70H110N24O23S6

1848.16

O=C1N2[C@](C(=O)N[C@@]3(C(=O)N[C@@H](C(C)C)C(=O)N[C@](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@H](C(N)=O)CSSC3)[H])(CSSC[C@@]4(NC(=O)[C@@H](N)CSSC[C@@](C(=O)N[C@H]1CC5=CN=CN5)(NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)C6(N(C(=O)[C@H]([C@@H](C)C)NC(=O)CNC4=O)C[C@H](O)C6)[H])[H])[H])[H])[H])(C[C@@H](O)C2)[H]

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Peptide