A-Helical Corticotropin Releasing Factor (12-41) - CAS 158535-55-8

α-Helical Corticotropin Releasing Factor (12-41), a 30-amino-acid α-helical analogue of corticotropin releasing factor/hormone (CRF), is a hypothalamic hormone that promotes adrenocorticotrophic hormone (ACTH) secretion. This compound counteracts CRF's stimulatory effect on ACTH secretion [1] [2].

CRFR

GPCR/G Protein

158472

C152H251N43O47S2

3497.01

[C@H](CC1=CN=CN1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CC(C)C)=O)C)=O)C)=O)CCC(N)=O)=O)CCC(O)=O)=O)C)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)C)=O)CCCCN)=O)C)=O)CCSC)=O)CCC(O)=O)=O)CC(C)C)=O)CCSC)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CC(C)C)=O)NC([C@H](CC2=CC=CC=C2)N)=O

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