Aβ-IN-1 - CAS 2766509-32-2

Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM) . Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ-IN-1 shows a sustained pharmacokinetic profile.

Beta Amyloid, Gamma-secretase

Stem Cells, Proteases/Proteasome, Neuroscience

2766475

0.9957

C35H49N

483.77

C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC=C1C=5C(CC2)=NC=6C(C5C)=CC=CC6)[H])[H]

-20°C

Ice Packs

Small Compound