A09-003 - CAS 2911646-14-3

A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.A09-003 also induces apoptosis, decreases RNA polymerase II activity, and decreases Mcl-1 expression.

Bcl-2 Family, Apoptosis, CDK

Cell Cycle/Checkpoint, Apoptosis

2911629

0.9984

C23H26N4O

374.48

N=1C=CC(=CC1NC2=CC=CC(=C2)N3CCNCCC3)C=4C=CC=CC4OC

-20°C

Ice Packs

Small Compound