A2AR modulator-1 - CAS 3007566-23-3

A2AR modulator-1 (Compound 45) is a selective negative allosteric modulator of the adenosine A2a receptor (A2aR), with an IC50 value of 9 nM. It reduces the affinity of endogenous adenosine for the receptor and inhibits the activation of the cAMP signaling pathway. A2AR modulator-1 effectively restores pCREB phosphorylation in CD4+ T cells, reverses immunosuppression in the tumor microenvironment, and shows potential in inhibiting tumor growth and metastasis in a triple-negative breast cancer model.

Adenosine Receptor

Neuroscience, GPCR/G Protein

3007540

C23H20N6

380.45

N#CC1=C(N=C(C(C#N)=C1C=2C=CC=C(C2)C3=CN=CC=C3)N4CCCCC4)N

-20°C

Ice Packs

Small Compound