A3373 - CAS 2324948-66-3

A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) of 325 nM for PLD1 and 15.15μM for PLD2. This compound effectively suppresses lipopolysaccharide (LPS) -induced immune responses and is implicated in key processes of autoimmune arthritis, bone demineralization, and osteoclastogenesis [1] [2].

Phospholipase

Metabolism

2324948-66-3

C17H9F7N2O

390.26

O=C(NC=1C=C(C=C(C1)C(F)(F)F)C(F)(F)F)C2=CC=3C=C(F)C=CC3N2

-20°C

Ice Packs

Small Compound