AACOCF3 - CAS 149301-79-1

AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid and a potent, selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2) . By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Additionally, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets, making it promising for cardiovascular disease research.

Phospholipase

Metabolism

149221

0.99

C21H31F3O

356.47

C(\CCCC(C(F)(F)F)=O)=C\C/C=C\C/C=C\C/C=C\CCCCC

-20°C

Ice Packs

Small Compound