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Molfinity

AB25583 - CAS 2565637-94-5

AB25583 - CAS 2565637-94-5

MF-0061565-01

$1,383.80 USD
$1,383.80 USD
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Product Details

  • Bioactivity

    AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.

  • Target

    DNA/RNA Synthesis, Others

  • Related Pathways

    Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair

  • CAS Number

    2565538

  • Molecular Formula

    C22H17ClN4O3S

  • Molecular Weight

    452.91

  • SMILES

    O=C(NC1=NN=C(OCC2=CC=C(Cl)C=C2)S1)C=3C=NC=CC3C=4C=CC=CC4OC

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound