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ABC1183 - CAS 1042735-18-1

ABC1183 - CAS 1042735-18-1

MF-0013062-01

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Product Details

  • Bioactivity

    ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, β-catenin phosphorylation and MCL1 expression, and is orally active.

  • Target

    GSK-3, CDK

  • Related Pathways

    Stem Cells, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint

  • CAS Number

    1042716

  • Purity

    0.9892

  • Molecular Formula

    C18H14N4OS

  • Molecular Weight

    334.39

  • SMILES

    Cc1ccc(Nc2nc(N)c(s2)C(=O)c2ccc(cc2)C#N)cc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound