Abd110 - CAS 3021581-79-0

Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].

ATM/ATR, PROTACs

PROTAC, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling

3021581-79-0

C41H42N8O7S

790.89

O=C(NC=1C=CC=CC1)C=2N=C(C=NC2N)C3=CC=C(C=C3)S(=O)(=O)NCCCCCC(=O)NCCCC#CC4=CC=CC=5C(=O)N(CC45)C6C(=O)NC(=O)CC6

-20°C

Ice Packs

PROTAC