Abemaciclib metabolite M18 - CAS 2704316-81-2

Abemaciclib metabolite M18 (LSN3106729) is a potent cyclin-dependent kinase (CDK) inhibitor with antitumor properties. It has been incorporated alongside a cereblon (CRBN) ligand to develop a proteolysis-targeting chimera (PROTAC) that selectively degrades CDK4/6 [1] [2].

Ligands for Target Protein for PROTAC, CDK

PROTAC, Cell Cycle/Checkpoint

2704233

C25H28F2N8O

494.54

C(C)(C)N1C=2C(N=C1CO)=C(F)C=C(C2)C3=NC(NC4=CC=C(CN5CCNCC5)C=N4)=NC=C3F

-20°C

Ice Packs

PROTAC