ACBI2 - CAS 2913161-19-8

ACBI2, an orally active and highly potent VHL PROTAC (EC 50: 7 nM), selectively degrades SMARCA2, demonstrating a DC 50 value of 1 nM in RKO cells. This compound holds potential for lung cancer research [1].

Epigenetic Reader Domain, PROTACs

PROTAC, Chromatin/Epigenetic

2913134

C56H68BrFN8O5S

1064.16

O=C1N=C2N(C=3C(N2C4CCCC4)=CC(=CC3)C5CCN(CC[C@H](CC[C@H](NC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)C(C)(C)C)=O)C[C@H](O)C6)C8=CC=C(C=C8)C9=C(C)N=CS9)C)CC5)C=%10C1=C(Br)C=CC%10

-20°C

Ice Packs

PROTAC