ACBI3 - CAS 2938169-76-5

ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.

Kras, Others, Ras, PROTACs

Others, MAPK, PROTAC, GPCR/G Protein

2938169-76-5

0.9924

C50H62N14O6S2

1019.25

C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C4=NC(=NC=C4)N5[C@@H](C)CN(CCCCOC6=CN([C@H](C(=O)N7[C@H](C(N[C@@H](CO)C8=CC=C(C=C8)C=9SC=NC9C)=O)C[C@@H](O)C7)C(C)C)N=N6)CCC5

-20°C

Ice Packs

Small Compound