AChE/BChE/BACE-1-IN-1 - CAS 1321361-13-0

AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1), with IC50 values of 0.058 μM, 0.082 μM, and 0.115 μM against hAChE, hBChE, and hBACE-1, respectively. It exhibits significant binding affinity with PAS-AChE, excellent blood-brain barrier permeability, potential disassembly of amyloid-beta (Aβ) aggregates, neuroprotective properties against Aβ-induced stress, and remarkable antioxidant capabilities [1].

Beta-Secretase, Cholinesterase (ChE), ROS Kinase, Others

Others, Neuroscience, Tyrosine Kinase/Adaptors

1321361-13-0

C19H21F3N2O

350.38

C(N1CC(NCC2=CC=C(OC(F)(F)F)C=C2)CC1)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound