AChE/GSK-3β-IN-1 - CAS 2412364-73-7

AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-3β (IC50: 22.4 nM) . AChE/GSK-3β-IN-1 is able to occupy the ATP binding site of DYRK1A. aChE/GSK-3β-IN-1 exhibits high kinase selectivity for the CMGC kinase family. aChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. aChE/GSK-3β-IN-1 can be used to study Alzheimer's disease.

Others, Microtubule Associated, ROS Kinase, Cholinesterase (ChE), GSK-3

Others, Stem Cells, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Neuroscience

2412284

C31H35N7O3S

585.72

N(CCNCC(NC1=CC(=CC=N1)C2=NC(OCC3CC3)=C(C(NC)=O)S2)=O)C4=C5C(=NC=6C4=CC=CC6)CCCC5

-20°C

Ice Packs

Small Compound