ACHP - CAS 406208-42-2

ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR) -driven gene expression through inhibition of NF-κB activation, inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR, and inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR. ACHKP has anti-HIV-1 activity and inhibits TNF-α-induced recruitment of NF-κB (p65) to the HIV-1 LTR.

Apoptosis, IκB/IKK, STAT

Apoptosis, Stem Cells, NF-κB, JAK/STAT signaling

406164

0.9877

C21H24N4O2

364.44

N#CC1=C(N=C(C=C1C2CCNCC2)C=3C(O)=CC=CC3OCC4CC4)N

-20°C

Ice Packs

Small Compound