Acid Ceramidase-IN-3 - CAS 2907705-12-6

Acid Ceramidase-IN-3 is an inhibitor of acid ceramidase (aCDase) . It shows a pIC50 of 8.5 in enzymatic assays and a pIC50 of 6.8 in A375 melanoma cell assays for aCDase enzyme activity inhibition. Acid Ceramidase-IN-3 promotes hepatic stellate cell (HSC) inactivation, measured by dose-dependent reduction of COL1A1 and ACTA2 levels. Additionally, it inhibits aCDase activity in HSCs, facilitating their inactivation and inhibiting YAP/TAZ nuclear localization. The compound enhances the expression of dynein/kinesin-related proteins (NDE1, NDEL1, KIF3B, KIF15) while reducing the expression of proteins related to various signaling pathways (SARM1, RGAP1, PDGF-D, PDGFR-B) . Acid Ceramidase-IN-3 is valuable for fibrosis disease research.

Others

Others

2907687

C27H26FN3O2

443.51

O=C(NCCCCC=1C=CC=CC1)N2C=NC(=C2)C=3C=CC(OCC4=CC=C(F)C=C4)=CC3

-20°C

Ice Packs

Small Compound