Aclacinomycin A hydrochloride - CAS 75443-99-1

Aclacinomycin A hydrochloride (Aclarubicin HCl) is an anthracycline antibiotic and inhibitor of topoisomerase I/II, interfering with DNA transcription and replication, inhibiting tumour invasion and angiogenesis, generating reactive oxygen species (ROS), and inhibiting the catalytic centre of the 20S proteasome. It is indicated for the treatment of relapsed leukaemia and advanced malignant lymphoma.

DNA/RNA Synthesis, ROS, DNA, Proteasome, Topoisomerase, Antibiotic

Cell Cycle/Checkpoint, Microbiology/Virology, Immunology/Inflammation, Proteases/Proteasome, DNA Damage/DNA Repair, Ubiquitination

75343

C42H54ClNO15

848.33

C(OC)(=O)[C@@H]1C2=C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@@H]5O[C@@H](C)C(=O)CC5)[C@H](C)O4)[C@H](C)O3)C[C@@]1(CC)O)C(O)=C6C(=C2)C(=O)C=7C(C6=O)=C(O)C=CC7.Cl

-20°C

Ice Packs

Natural Product