ACT-672125 - CAS 1449367-94-5

ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner.

Others, CXCR

Autophagy, Immunology/Inflammation, GPCR/G Protein, Others

1449268

C25H25F3N10O2S

586.59

C(F)(F)(F)C1=NC(=C(S1)N2C[C@@H](C)N(C(CN3C(C)=NC(C)=N3)=O)CC2)C=4NC=5C(N4)=CC=C(C5)C6=NOC(C)=N6

-20°C

Ice Packs

Small Compound