AD1058 - CAS 2907782-78-7

AD1058 is a potent and selective ATR inhibitor (IC50 = 1.6 nM) that crosses the blood-brain barrier with significant in vivo anticancer activity. It is commonly used in the study of brain metastasis and CNS metastasis by inhibiting cell proliferation, disrupting the cell cycle and inducing apoptosis.

Src, Apoptosis, AMPK, ATM/ATR, mTOR

Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, DNA Damage/DNA Repair

2907697

0.9824

C19H20N6O3S

412.47

C[C@H]1N(C2=C3C(=NC(=N2)C4=C5C(=NC=C4)NC=C5)N(S(C)(=O)=O)C=C3)CCOC1

-20°C

Ice Packs

Small Compound