AD4 - CAS 2918262-09-4

AD4, an artemisinin derivative functioning as a proteolytic targeting chimera (PROTAC) for PCLAF, effectively degrades PCLAF in RS4;11 cells with an IC50 of 0.6 nM. This degradation activates the p21/Rb axis, resulting in antitumor activity. Furthermore, AD4 has been demonstrated to prolong survival in NOD/SCID mice transplanted with RS4;11 cells, showcasing its in vivo efficacy [1].

PROTACs

PROTAC

2918262-09-4

C55H78N4O15

1035.23

C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1OCCN(CCO[C@H]5O[C@]6([C@]78[C@]([C@H]5C)(CC[C@@H](C)[C@@]7(CC[C@](C)(O6)OO8)[H])[H])[H])C(CCCCCCCNC9=C%10C(C(=O)N(C%10=O)C%11C(=O)NC(=O)CC%11)=CC=C9)=O)[H])[H]

-20°C

Ice Packs

PROTAC