AD57 (hydrochloride) - CAS 2320261-72-9

AD57, as polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer blocks the receptor tyrosine kinase RET in Drosophila (IC50: 2 nM) . AD57 effectively suppresses tyrosine kinase RET, weakens the activity of numerous other kinases, and interferes with kinases downstream of RET, including Raf, Src, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism-related to cancer. Tyrosine kinase RET is probably sufficient to initiate a series of transformation events including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A, and 2B.

Others, Src, c-RET, Raf, S6 Kinase

Tyrosine Kinase/Adaptors, Apoptosis, PI3K/Akt/mTOR signaling, MAPK, Angiogenesis, Others

2320180

C22H21ClF3N7O

491.9

Cl.CC(C)n1nc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2c(N)ncnc12

-20°C

Ice Packs

Small Compound