Adenosine receptor antagonist 6 - CAS 2913578-04-6

Adenosine receptor antagonist 6 is an orally active, selective (S) -enantiomer compound that acts as an A2A adenosine receptor (A2AAR) antagonist. It binds to the A2A adenosine receptor with a Ki value of 19.18 nM. This antagonist inhibits cAMP production mediated by 5’-N-ethylcarboxamide adenosine (NECA) with an IC50 value of 0.089 μM and reduces immunosuppression, while enhancing the secretion of IL-2 and IFN-γ. It counteracts adenosine-induced immunosuppression in T cell activation and cytokine release and inhibits tumor growth in CT26/MC38 xenograft models, making it applicable for colorectal cancer research.

Interleukin, Adenosine Receptor, Cytochromes P450, IFNAR

Metabolism, Neuroscience, GPCR/G Protein, Immunology/Inflammation

2913578-04-6

C18H16N6O

332.36

NC=1C=2N(C=3C(N2)=CC=CC3)C=C(C(N[C@@H](C)C4=CC=CC=N4)=O)N1

-20°C

Ice Packs

Small Compound