ADH-6 - CAS 2227429-65-2

ADH-6, a tripyridylamide compound, impedes the self-assembly of the aggregation-nucleating subdomain of mutant p53 DNA-binding domain (DBD) . By targeting and dissociating mutant p53 aggregates in human cancer cells, ADH-6 reinstates p53's transcriptional activity, culminating in cell cycle arrest and apoptosis, thereby holding potential for cancer research.

Others, MDM-2/p53, Apoptosis

Others, Apoptosis

2227362

C29H36N8O9

640.64

N(C(=O)C=1N=C(OCCCC)C(N(=O)=O)=CC1)C2=C(OCCCN)N=C(C(NC3=C(OCCCN)N=C(C(OC)=O)C=C3)=O)C=C2

-20°C

Ice Packs

Small Compound