ADMA-d6 - CAS 1313730-20-9

NG, NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG, NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS) . It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2) . ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet. ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.

Endogenous Metabolite, NO Synthase

Metabolism, Immunology/Inflammation

1313701

C8H14D6Cl2N4O2

281.2106

Cl.Cl.[2H]C([2H])([2H])N(C(=N)NCCC[C@H](N)C(O)=O)C([2H])([2H])[2H]

-20°C

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