AEG40730 HCl - CAS 1883545-50-3

AEG40730 is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG40730 binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in RIP1 ubiquitination. Treatment with nanomolar concentrations of AEG40730 resulted in the loss of both XIAP and c-IAP1 proteins, albeit with different kinetics.

Others

Others

1883492

C52H70Cl2F6N8O8

1120.0704

Cl.Cl.CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)OCC#CC#CCO[C@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N1CCC[C@H]1CN(CCc1ccccc1)C(=O)C(F)(F)F)C(=O)N1CCC[C@H]1CN(CCc1ccccc1)C(=O)C(F)(F)F

-20°C

Ice Packs

Small Compound