AES-350 - CAS 847249-57-4

AES-350 is a potent and orally active HDAC6 inhibitor (IC50 and Ki of 0.0244 μM and 0.035 μM, respectively), also exhibiting activity against HDAC-3, -8, and -11 in an enzymatic assay with IC50 values of 0.187 μM, 0.245 μM, and >1 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.

Apoptosis, HDAC

Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis

847188

0.992

C18H20N2O3

312.36

CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)NO

-20°C

Ice Packs

Small Compound