AF3442 - CAS 924636-93-1

AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1) . AF3442 caused a concentration-dependent inhibition of PGE (2) in human recombinant mPGES-1 with an IC (50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE (2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH (2) metabolism towards other terminal PG synthases in monocytes. The functional relevance of this observation deserves to be investigated in vivo.

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Others

924542

C22H17F3N2O

382.38

C(C)N1C=2C(C=3C1=CC=CC3)=CC(NC(=O)C4=C(C(F)(F)F)C=CC=C4)=CC2

-20°C

Ice Packs

Small Compound