AF3485 - CAS 1195786-61-8

AF3485, a human mPGES-1 inhibitor, exhibits anti-tumor activity both in vitro and in vivo. It achieves this by reducing PGE2 production, inhibiting EGFR signaling, and decreasing the expression of VEGF and FGF-2, which suppresses tumor-associated angiogenesis. When subchronically administered to mice with human A431 xenograft tumors, AF3485 effectively curtails tumor growth.

1195786-61-8

C22H17F3N2O2

398.38

O=C(NC1=CC=C2C(=C1)C=3C=CC=CC3N2CCO)C=4C=CC=CC4C(F)(F)F

-20°C

Ice Packs

Small Compound