Afatinib - CAS 850140-72-6

Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively.

C-Met/HGFR, Autophagy, EGFR, Apoptosis, p38 MAPK, Akt

MAPK, JAK/STAT signaling, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors, Apoptosis, Autophagy, Angiogenesis, PI3K/Akt/mTOR signaling

850062

0.999

C24H25ClFN5O3

485.94

N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4

-20°C

Ice Packs

Small Compound