Afatinib Dimaleate - CAS 850140-73-7

Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity.

Apoptosis, p38 MAPK, Akt, c-Met/HGFR, HER, Autophagy, EGFR

Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Angiogenesis, Autophagy, JAK/STAT signaling, Cytoskeletal Signaling, Apoptosis, MAPK

850060

>99.99%

C32H33ClFN5O11

718.08

OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1

-20°C

Ice Packs

Small Compound