Afatinib oxalate - CAS 1398312-64-5

Afatinib (BIBW 2992) oxalate is an irreversible, orally active bispecific inhibitor of the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFRwt, 0.4 nM for EGFRL858R, 10 nM for EGFRL858R/T790M, and 14 nM for HER2. Afatinib oxalate can be used to study esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), and gastric cancer.

Others, Apoptosis, Akt, c-Met/HGFR, EGFR, Autophagy

Others, Cytoskeletal Signaling, JAK/STAT signaling, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Angiogenesis, Apoptosis, Autophagy

1398243

C28H29ClFN5O11

666.01

OC(=O)C(O)=O.OC(=O)C(O)=O.CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1

-20°C

Ice Packs

Small Compound