Afegostat TFA - CAS 1084896-50-3

Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K (i) ~30 nM for wild-type and mutant enzymes (N370S and V394L) . Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain extracts.

Others, glycosidase

Others, Metabolism

1084843

C8H14F3NO5

261.2

C(C(O)=O)(F)(F)F.C(O)[C@@H]1[C@@H](O)[C@H](O)CNC1

-20°C

Ice Packs

Small Compound