Afeletecan free base - CAS 215604-75-4

Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double-strand DNA breakage, and triggering of apoptosis.

Others

Others

215525

C45H49N7O11S

895.98

O(C([C@@H](NC([C@H](CC1=CN=CN1)NC(NC2=CC=C(O[C@@H]3[C@@H](O)[C@H](OC)[C@H](O)[C@H](C)O3)C=C2)=S)=O)C(C)C)=O)[C@@]4(CC)C5=C(C(=O)N6C(=C5)C=7C(C6)=CC=8C(N7)=CC=CC8)COC4=O

-20°C

Ice Packs

Small Compound