Afizagabar - CAS 1398496-82-6

Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. It enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy [1].

GABA Receptor, Others

Membrane transporter/Ion channel, Others, Neuroscience

1398408

C19H12FN3O2S

365.38

CC1=NN=C(c2cc3c(F)cccc3s2)c2cc3oc(=O)[nH]c3cc2C1

-20°C

Ice Packs

Small Compound