AFN-1252 tosylate hydrate - CAS 1047981-30-5

AFN-1252, also known as AFN-12520000; API-1252; Debio-1452, is FASII Inhibitor which is potentially for the treatment of acute bacterial skin. AFN-1252 exhibits typical MIC (90) values of ≤0·015 μg/ml against diverse clinical isolates of S. aureus, oral absorption, long elimination half-live and efficacy in animal models. AFN-1252 efficiently blocked daptomycin-induced phospholipid decoy production, even in the case of isolates resistant to AFN-1252, which prevented the inactivation of daptomycin and resulted in sustained bacterial killing. In turn, daptomycin prevented the fatty acid-dependent emergence of AFN-1252-resistant isolates in vitr

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1047946

C29H31N3O7S

565.64

S(=O)(=O)(O)C1=CC=C(C)C=C1.CC=1C=2C(OC1CN(C(/C=C/C=3C=C4C(NC3)=NC(=O)CC4)=O)C)=CC=CC2.O

-20°C

Ice Packs

Small Compound