Aftin-5 - CAS 1461717-05-4

Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42) . It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.

Beta Amyloid

Neuroscience

1461717-05-4

C19H26N6O

354.45

N(C)(C1=C2C(N(C(C)C)C=N2)=NC(N[C@H](CC)CO)=N1)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound