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Molfinity

AG126 - CAS 118409-62-4

AG126 - CAS 118409-62-4

MF-0012974-01

$39.90 USD
$39.90 USD
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Product Details

  • Bioactivity

    AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in vivo, attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in diverse animal models. AG-126 weakly inhibits epidermal GFRK (IC50: 450 μM) and platelet-derived GFRK (IC50 > 100 μM) .

  • Target

    COX, ERK

  • Related Pathways

    Immunology/Inflammation, MAPK, Neuroscience

  • CAS Number

    118343

  • Purity

    0.9872

  • Molecular Formula

    C10H5N3O3

  • Molecular Weight

    215.16

  • SMILES

    Oc1cc(C=C(C#N)C#N)ccc1[N+]([O-])=O

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound