AG311 - CAS 1126602-42-3

AG311 is an inhibitor of complex I and hypoxia-induced HIF-1α stabilization. In vitro, AG311 induces rapid necrosis in numerous cancer cell lines. Within minutes, exposure to AG311 also results in mitochondrial depolarization, superoxide production, and increased intracellular calcium levels.

Others, Necroptosis

Others, Apoptosis

1126557

C17H15N5S

321.4

S(C1=C2C=3C(NC2=CC=C1)=NC(N)=NC3N)C4=CC=C(C)C=C4

-20°C

Ice Packs

Small Compound